Scientist / Junior Scientist in Biomolecular NMR...

Job Description

Under the supervision of the Head of NMR, you will join a multidisciplinary Structural Biology and Biophysics team supporting pharmaceutical and biotechnology clients in their drug discovery programs.

Working closely with experts in Surface Plasmon Resonance (SPR), Native Mass Spectrometry, HDX-MS, Cryo-EM and X-ray Crystallography, you will contribute to the characterization of biomolecular interactions and the structural investigation of proteins and protein-ligand complexes.

You will be expected to:

• Design, perform and interpret advanced biomolecular NMR experiments for protein and protein-ligand characterization.

• Conduct ligand-observed and protein-observed NMR assays to support hit identification, hit validation and fragment-based drug discovery projects.

• Perform multidimensional NMR analyses to characterize binding events, chemical shift perturbations and structural changes induced by ligand binding.

• Independently perform resonance assignments using state-of-the-art methodologies and computational tools.

• Analyze and interpret NMR datasets to provide structural and mechanistic insights supporting client projects.

• Contribute to the development, validation and implementation of new NMR methodologies and applications.

• Prepare protocols, SOPs and technical documentation.

• Present results to internal teams and clients through written and oral reports.

• Participate in troubleshooting activities and continuous improvement of NMR workflows and instrumentation.

Profile

We are looking for a dynamic, motivated and scientifically curious NMR scientist to join the Structural Biology and Biophysics team.

Major Requirements

• PhD in Structural Biology, NMR Spectroscopy, Biophysics

• Strong theoretical and practical expertise in biomolecular NMR spectroscopy.

• Hands-on experience operating high-field NMR spectrometers (600, 700 and/or 800 MHz).

• Proven experience in the characterization of protein-ligand interactions using ligand-observed and/or protein-observed NMR approaches.

• Experience with multidimensional NMR experiments and resonance assignment strategies.

• Ability to independently analyze complex datasets and derive biologically relevant conclusions.

• Excellent written and verbal communication skills in English.

• Strong organizational skills and ability to manage multiple projects simultaneously.

• Ability to work efficiently in a multidisciplinary and client-oriented environment.

Additional Assets

• Experience in fragment-based drug discovery (FBDD).

• Knowledge of complementary biophysical techniques such as SPR, MST, ITC, DLS or Native MS.

• Experience in method development and automation of NMR workflows.

Personal Skills

• Strong analytical and problem-solving abilities.

• Scientific rigor and experimental autonomy.

• Ability to translate complex structural information into actionable project recommendations.

• Excellent communication and presentation skills.

• Collaborative mindset and team spirit.

• Curious, innovative and proactive attitude.

• Strong client-service orientation.

Languages

• Fluent English, written and spoken.

Start of contract: as soon as possible.

Type of contract: permanent position.