Lead researcher position in Biomaterials and Bioengineering

This project aims to develop innovative strategies for generating osteogenic grafts for the regeneration of congenital or acquired bone defects. The approach is based on the principles of endochondral ossification, seeking to reproduce the key stages of bone development to improve graft vascularization, integration, and functionality. The objective is to utilize readily available human cells (particularly those derived from adipose tissue or other relevant mesenchymal sources) and combine them with instructive biomaterials capable of directing their differentiation toward a chondrogenic and then an osteogenic phenotype. Attention will be paid to the design of microenvironments combining structural supports, biochemical signals (growth factors, morphogens), and potentially biophysical stimuli (mechanical, electrical, or electromagnetic) to optimize the robustness and reproducibility of the regenerative process. The project will integrate advanced biofabrication approaches, such as 3D bioprinting and the development of tailored bio-inks, enabling control over graft architecture as well as the spatial distribution of cells and bioactive signals. This program is part of a strong translational dynamic, with evaluation in relevant preclinical models of bone defects and close collaboration with clinical partners of the laboratory.

The candidate will be involved in the Biomaterials Master's degree which is organized in 2 courses within the University of Strasbourg: Biomaterials and Bioengineering of Health and Intelligence in Health Data (master’s level M1 and M2). Innovative pedagogical practices will be considered. He will be strongly involved in the supervision of the Unit's student interns (Bachelor's, Master's, Engineering levels) and in the supervision of doctoral students.

Company

Founded in 1964, Inserm is a public scientific and technological institute which operates under the joint authority of the French Ministries of Health and Research. The institute is dedicated to biomedical research and human health, and is involved in the entire range of activities from the laboratory to the patient’s bedside. It also partners with the most prestigious research institutions in the world that are committed to scientific challenges and progress in these fields. Inserm brings together 15,000 researchers, engineers, technicians and administrative staff, all with one shared objective: improve health by advancing knowledge about living organisms and diseases, developing innovative treatment modalities and conducting research on public health.

Company info

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Telephone

+33144236277

Location

101 Rue de Tolbiac
Paris
Paris
75013
France